At least 90 people were killed in a nightclub fire caused by a pyrotechnics show in the southern Brazilian city of Santa Maria, local media reported on Sunday.
As 2,000 people were in the nightclub when the fire started, and that police were still counting the dead.
Reports say there was only one exit and panic spread as people tried to get out. Many victims reportedly died from inhaling toxic fumes.
The fire is now out and bodies are being removed from the scene.
Fire crews reportedly knocked through a wall to help those trapped inside escape.
The death toll could be as high as 130